A standard installation involves several critical directories that you may need to create or modify manually:
On first run, Ryujinx creates its data folder in the user’s profile directory. This is the installation directory, but the Ryujinx data folder . ryujinx folder new
How To Transfer Saved Files From One Switch Emulator To Another you may need to create:
Within an existing Ryujinx setup, you may need to create: ryujinx folder new