Some homebrew loaders for consoles like the PS3 (with multiMAN) or Wii U (with Loadiine) expect game files in ISO or folder format. You could put a Z64 inside an ISO, but the loader would still need an emulator to run it—inefficient, but possible.
This feature allows users to convert Nintendo 64 ROM files ( .z64 ) into ISO 9660 format ( .iso ). This is primarily used for: z64 to iso
for playing or emulating Nintendo 64 games. The correct approach is to keep Z64 files as-is for emulators or flashcarts. Wrapping a Z64 inside an ISO is possible only for storage/archival, not for execution. Some homebrew loaders for consoles like the PS3