ISE 14.7 relies on a legacy windrvr6 kernel driver for its Platform Cable USB (Model DLC9, DLC9LP, or DLC10). Windows 10’s Driver Signature Enforcement and architecture changes break this driver entirely. Without this, you cannot program hardware.
, which are not supported by the newer Vivado platform. Running it on Windows 10 is notoriously difficult because the native version was designed for Windows 7/XP and frequently crashes or fails to open on modern operating systems. Critical Compatibility Overview Virtual Machine (VM) Requirement
: Get the "Full Installer for Windows 7/XP/Server" (6.18 GB).