It can be played on original PS2 hardware if the console is modded (e.g., using FreeMcBoot and OPL) to load ISO files from a USB or hard drive.
For over a decade, the Guitar Hero franchise has been the gold standard for rhythm gaming. While modern titles come and go, a dedicated community of players refuses to let the plastic guitar die. Among the most sought-after relics in this underground scene is the elusive — a custom expansion that pushes the boundaries of the classic PS2 era. new download guitar hero 2 extreme vol 2 iso
Because it is an unofficial ISO, you cannot play it on an unmodded PlayStation 2 console with a retail disc. It can be played on original PS2 hardware